Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene.
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase.
The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking.
No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response.
This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule.
The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus.
This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.
Applications: Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O.
Specificity：Recognizes human VNN1.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human WNN1 (Position: Q22-K192), expressed in E. coli. Species sequence homology: mouse (82.2%)
