84-4453-93　KRIT1, CT (Krev Interaction Trapped Protein 1) 100ug　370998

特徴

• Krev interaction trapped protein 1(KRIT1) is a protein that in humans is encoded by the CCM1 gene.
• This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences.
• The encoded protein is localized in the nucleus and cytoplasm.
• It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation.
• It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions.
• It is also a microtubule-associated protein and may play a role in microtubule targeting.
• Mutations in this gene result in cerebral cavernous malformations.
• Multiple alternatively spliced transcript variants have been found for this gene.
• Applications: Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.