84-4453-61　FGF19 (Fibroblast Growth Factor 19) 100ug　370966

特徴

• FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene.
• The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family.
• The FGF19 gene is mapped to 11q13.3.
• The deduced 216-amino acid FGF19 protein contains a signal sequence and 2 cysteine residues that are conserved in the FGF family.
• Expression of this gene was detected only in fetal but not adult brain tissue.
• Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
• FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis.
• The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity.
• The orthologous protein in mouse is FGF15, which shares about 50% amino acid identity and has similar functions.
• Together they are often referred to as FGF15/19.
• Applications: Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.