SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of the cell fate (1).
The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins (2).
This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development (2).
Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschprung disease (3).
SLC30A8 expression in beta-cells was found to be influenced by cytokine expression, particularlyIFN-gamma and IL-1beta (4).
Applications:Suitable for use in ELISA, Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human SOX10. Species Crossreactivity: mouse, rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to 18aa of human SOX10 at N-terminal. Species sequence homology: chicken (89%), goat (100%), porcine (100%)
