Caveolin-1 is a scaffolding protein that is the main component of the caveolae plasma membranes found in most cell types (1).
The protein links integrin subunits to the tyrosine kinase FYN, aninitiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression (2).
The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinasecascade (3).
Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy (4).
Applications:Suitable for use in ELISA, Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human Caveolin-1. Species Crossreactivity: mouse, rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Ch Hu Mo Rt
Immunogen：Synthetic peptide corresponding to 18aa of human Caveolin-1 at N-terminal. Species sequence homology: chicken (88%), rabbit (100%), equine (100%), sheep (100%), bovine (100%), porcine (100%)
