84-4451-23　Noxa (Phorbol-12-Myristate-13-Acetate-Induced Protein 1, Protein Noxa, Pmaip1) (APC) 100ul　N5376-80F-APC

特徴

• Noxa is an 11kD member of the BH3-only proapoptotic protein family.
• Noxa is localized to the mitochondria and is a transcriptional target of p73, p53 and BH3-only proteins.
• It is thought to induce apoptosis when activated, lowering the activity of anti-apoptotic Bcl-2-like proteins.
• It can be upregulated by mitogenic activation, independently of p53.
• In humans, along with Mcl-1 it is thought to form a selective pathway that restrains lymphocyte proliferation.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: APC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.