SUZ12 has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma.
The protein encoded by this gene contains a zinc finger domain in the C terminal of the coding region.
The specific function of this gene has not yet been determined.
Suz12 mutants exhibited very strong homeotic transformations and that Suz12 function is required throughout development to maintain the repressed state of Hox genes in Drosophila.
Unlike most other Polycomb group mutations, Suz12 mutations are strong suppressors of position-effect variegation, suggesting that Suz12 also functions in heterochromatin-mediated repression.
Furthermore, Suz12 function is required for germ cell development.
The SUZ12 protein is highly conserved in vertebrates and is also related to several Arabidopsis proteins.
Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
