84-4448-26　［受注停止］SATB1 (SATB Homeobox Protein 1, DNA-binding protein SATB1, Special AT-Rich Sequence Binding Protein 1 (Binds To Nuclear Matrix/Scaffold-Associating DNA's)) 200ul　369628

特徴

• SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation.
• Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli.
• At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin.
• SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances.
• Silencing of SATB1 mimics the effects of IFN-gamma treatment on chromatin loop architecture of the MHC class I locus and altered expression of genes within the locus.
• SATB1induce breast cancer tumor growth and metastasis through the altered expression of large numbers of genes.
• Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.