Regulator of G-protein signaling 3 is a member of the regulator of G-protein signaling (RGS) family.
This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction.
The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane.
A nuclear form of this protein has also been described, but its sequence has not been identified.
Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form.
Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases.
Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
