LYVE1 encodes a type I integral membrane glycoprotein.
The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan.
This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.
LYVE-1 is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, and sort these cells for experimental purposes.
Sequence analysis predicted that the 322aa type I integral membrane glycoprotein is 41% similar to CD44.
LYVE1 contains a leader peptide; a 212-residue extracellular domain with 7 cysteine residues, a serine/threonine-rich region, and 2 potential N-linked glycosylation sites; a 21aa transmembrane domain; and a 63-residue cytoplasmic tail.
Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
