2'-5'-oligoadenylate synthetase 3 is an enzyme included in the 2', 5' oligoadenylate synthase family.
This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L.
This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
The domains share 44 to 60% protein sequence similarity with each other and 42 to 60% sequence identity with the conserved domain of OAS1.
The authors noted that OAS1, OAS2, and OAS3 contain 1, 2, and 3 conserved OAS domains or units, respectively.
Northern blot analysis revealed that OAS3 is expressed as a 7-kb interferon-induced mRNA in HeLa cells.
Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
