84-4445-88　MMP9 (MMP9, Matrix Metalloproteinase 9, Gelatinase B, 92kD Gelatinase, 92kD Type IV Collagenase, HGNC:7176, CLG4B, GELB, 92kD Type IV Collagenase, GelatinaseB, Macrophage Gelatinase, Matrix Metalloproteinase 9 (Gelatinase B, 92kD Gelatinase, 92kD Type IV Collagenase), Type V Collagenase) 100ug　368538

特徴

• Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
• Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.
• The enzyme encoded by this gene degrades type IV and V collagens.
• Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Peptide ELISA: 1:64,000Western Blot:1-3ug/ml, bands at ~80kD and 70kD in Human Peripheral Blood Mononucleocytes lysates.
• These bands correspond to the mature forms This protein has a calculated MW of 78.5kD according to NP_004985.2, but the precursor is usually seen as 92kD or larger
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.