This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors.
The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria.
Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription.
Some isoforms dominantly inhibit the activity of other estrogen receptor family members.
Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Peptide ELISA: 1:128,000Immunohistohemistry (paraffin): 3-5ug/ml, paraffin embedded human placenta shows staining of syncytiotrophoblastsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human ESR2. Expected to recognize all three isoforms (NP_001035365.1; NP_001035366.1; NP_001428.1)
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to RRQRSADEQLHC of human ESR2(NP_001035365.1; NP_001035366.1; NP_001428.1).
