The presenilin-2 (PS-2) gene was discovered on chromosome 1 and is responsible for an early onset form of autosomal dominant Alzheimer's disease (AD).
The amino acid sequence is approximately 67% identical with that of the PS-1 protein.
It also is a membrane protein that has regions where mutations have been identified in family members with AD.
The gene sequence of PS-2 does not match any known human gene sequences, except for that of PS-1; but has been found to be a new class of aspartic-proteases.
It has now been identified as one of the secretase proteases.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:20,000Immunohistochemistry: 1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：goat
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a liquid. No preservative added.
Specificity：Recognizes human Presenilin-2.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human Presenilin 2 (CQEGRQGPEDGENTAQW).
