Non-receptor tyrosine-protein kinase TYK2 is a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families.
This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits.
It is also component of both the type I and type III interferon signaling pathways.
As such, it may play a role in anti-viral immunity
Cytokines play pivotal roles in immunity and inflammation by regulating the survival, proliferation, differentiation and function of immune cells as well as cells from other organ systems.
Hence, targeting cytokines and their receptors is an effective means of treating such disorders.
Type I and II cytokine receptors associate with Janus family kinases (JAKs) to effect intracellular signaling.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human tyk2.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Cys915-His1173 of human Tyk2, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
