TRPV2encodes an ion channel that is activated by high temperatures above 52 °C.
The protein may be involved in transduction of high-temperature heat responses in sensory ganglia.
It is thought that in other tissues the channel may be activated by stimuli other than heat.TRPV2 is activated by high temperatures above 52 °C.
Alternatively it can be activated at lower temperatures by chemicals, such as the research tool 2-APB, the plant cannabinoid cannabidiol, and probenecid.
It is blocked by ruthenium red and lanthanum
TRPV2 was independently discovered by two research groups and described in 1999.
It was identified in the lab of David Julius as a close homolog of TRPV1, the first identified thermosensitive ion channel.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes mouse TRPV2.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Mo
Immunogen：Recombinant protein corresponding to Met1-His264 of mouse TRPV2, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
