84-4440-52　TREM1 (Triggering Receptor Expressed On Myeloid Cells 1, CD354, Triggering Receptor Expressed On Monocytes-1) 200ul　365435

特徴

• TREM-1 is a Type I membrane protein that contains an immunoglobulin-like V-type domain.
• An alternatively spliced protein variant may be secreted.
• TREM-1 is expressed in monocytes and neutrophils but not in lymphocytes, dendritic cells or other cell types.
• TREM1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide.
• TREM-1 is a glycoprotein that is reduced by deglycosylation, in agreement with the predicted molecular mass.
• TREM-1 is an activating receptor of the Ig superfamily that is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes).
• TREM1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- AEVFEEKCT LAEGQTLKVS CPTNTNIYSN SQKAWQRLKD NGEVQTLAIT EGSSQVRVGK YFLEDIPSEG MLQIQMANLQ VEDSGLYRCV ILGPSDPIIL FHPVRLVVTK NSLGTPASDE YPCQVSVQNP TPLPVTTKLR PRPRPRPKPV TQPIPTSADR LSSPGFTVTP TNVTHVNRAP GISIIIPAAC GLLSKTLVFI GLFAVTHRSF AS
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.