Tumor necrosis factor ligand superfamily member 12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family.
This protein is a ligand for the FN14/TWEAKR receptor.
This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution.
This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner.
This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.
The deduced in-frame fusion protein, which the authors called TWEPRIL, has a calculated molecular mass of 38kD.
TWEPRIL begins at the initiation codon of TWEAK and contains the intracellular, transmembrane, and stalk regions of TWEAK fused to the extracellular receptor-binding domain of APRIL.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 0.2-2ug/mlImmunohistochemistry: 5-20ug/mlImmunocytochemistry: 5-20ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.01% SKL, 1mM DTT, 5% trehalose, Proclin300.
Specificity：Recognizes mouse TNFSF12.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Mo
Immunogen：Recombinant protein corresponding to Gln53-His249 of mouse TNFSF12, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
