84-4439-32　［受注停止］TJP2 (Tight Junction Protein 2, X104, ZO-2, ZO2, Zona Occludens 2, Friedreich Ataxia Region Gene X104, Zona occludens protein 2, Zonula occludens protein 2) 200ul　365316

特徴

• TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family.
• The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions.
• Mutation in this gene have been identified in patients with hypercholanemia.
• Alternate splicing results in multiple transcript variants.
• This protein is found in epithelial cell junctions.
• Isoform A1 is abundant in the heart and brain whereas isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta.
• In brain and skeletal muscle, only isoform A1 is detectable.
• Isoform C1 is found in normal as well as in most neoplastic tissues while isoform A1 is present almost exclusively in normal tissue.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.