84-4439-16　Tie1 (Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1, JTK14, Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1, Tyrosine-protein kinase receptor Tie-1) 200ul　365300

特徴

• Tie1 is a cell surface protein expressed exclusively in endothelial cells.
• Tie1 upregulates the cell adhesion molecules VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism.
• Attachment of monocyte derived immune cells to endothelial cells is also enhanced by Tie1 expression.
• Tie1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.
• the combinatorial function of angiopoietin-1 and the orphan receptor TIE1 is critical for the development of the right-hand side venous system but is dispensable for the left-hand side venous system.
• This finding revealed the existence of a distinct genetic program for the establishment of the right-hand side and left-hand side vascular networks well before the network asymmetry becomes morphologically discernible.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.