84-4439-13　TICAM1 (Toll Like Receptor Adaptor Molecule 1, TRIF, PRVTIRB, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, Proline-rich, vinculin and TIR domain-containing protein B) 200ul　365297

特徴

• TRIF is primarily active in the spleen and is often regulated when MyD88 is deficient in the liver, indicating organ-specific regulation of signaling pathways.
• Curiously, there is a lack of redundancy within the TLR4 signaling pathway that leads to microbial evasion of immune response in the host after mutations occur within intermediates of the pathway.
• Three TRAF-binding motifs present in the amino terminal region of TRIF are necessary for association with TRAF6.
• Destruction of these motifs reduced the activation of NF-kappa Beta, a transcription factor that is also activated by the carboxy-terminal domain of TRIF in the upregulation of cytokines and co-stimulatory immune molecules.
• This domain recruits receptor-interacting protein (RIP1) and RIP3 through the RIP homotypic interaction motif.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.