TCN2 encodes a member of the vitamin B12-binding protein family.
This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions.
This plasma protein binds cobalamin and mediates the transport of cobalamin into cells.
This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene.
Deficiency in TC II was demonstrated.
A partial deficiency in both parents and other hematologically normal relatives indicated autosomal recessive inheritance.
Decreased intestinal absorption of B12, uncorrected by intrinsic factor, suggested that transcobalamin II is involved in B12 absorption.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human TCN2.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Glu19-Trp427 of human TCN2, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
