84-4438-57　TCL1A (T-Cell Leukemia/Lymphoma Protein 1A, Tgtp, TCL1A, TCL1, T-Cell Specific GTPase, Oncogene TCL1, Protein p14 TCL1) 200ul　365243

特徴

• TCL1, is situated at 14q32.3 and is activated when it comes into juxtaposition with the TCRA locus with inversion;.
• Erikson et al.
• showed that the TCRA locus is split between the proximal V gene and the more distal C gene by the breakpoint at 14q11.2 that creates of T-cell leukemia.
• Mathieu-Mahul et al.
• cloned a DNA fragment from 14q11 in a case of T-cell malignancy.
• Mengle-Gaw et al.
• and Davey et al.
• both studied chromosome rearrangements, inversions, or translocations, involving 14q in patients with ataxia-telangiectasia.
• These patients are prone to the development of lymphatic neoplasms in association with these abnormalities.
• Mengle-Gaw et al.
• concluded that a single locus at chromosome band 14q32.1, located about 15-20 million basepairs centromeric to the IGH locus, is critical to the development of neoplasia.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap