84-4437-70　［受注停止］SPINK1 (Serine Peptidase Inhibitor Kazal Type 1, PCTT, PSTI, TATI, Tumor-Associated Trypsin Inhibitor, Pancreatic secretory trypsin inhibitor, Tumor-associated trypsin inhibitor0 200ul　365155

特徴

• SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice.
• It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct.
• Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.
• The 79aa sequence contains a 23aa signal peptide followed directly by the 56aa mature secreted form.
• Tumor-associated trypsin inhibitor (TATI) is identical to PSTI.
• TATI is a 6kD peptide that is synthesized by several tumors and cell lines.
• It was initially detected in urine of patients with ovarian cancer.
• This peptide is also produced by the mucosa of the gastrointestinal tract where it may protect the mucosal cells from proteolytic breakdown.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• AA Sequence:MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-LGREA KCYNELNGCT KIYDPVCGTD GNTYPNECVL CFENRKRQTS ILIQKSGP
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.