84-4437-40　SOD1 (Superoxide Dismutase 1, Soluble, ALS, ALS1, IPOA, Amyotrophic Lateral Sclerosis 1, Adult, Superoxide dismutase [Cu-Zn]) 200ul　365125

特徴

• Superoxide dismutase 1, solubleis a human protein and gene.
• This gene encodes one of three forms of the human superoxide dismutase.
• SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body.
• The encoded isozyme is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide.
• Mutations (over 100 identified to date) in this gene have been linked to familial amyotrophic lateral sclerosis.
• The most frequent mutation are A4V (in the U.S.
• A.) and H46R (Japan).
• The most studied ALS mouse model is G93A.
• Rare transcript variants have been reported for this gene.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- ALKAVCVLK GDGPVHGVIH FEQQQEGGPV VLKGFIEGLT KGDHGFHVHE FGDNTQGCTT AGAHFNPLSK KHGGPKDEER HVGDLGNVTA DENGKADVDM KDSVISLSGK HSIIGRTMVV HEKQDDLGKG GNEESTKTGN AGSRLACGVI GIAP
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.