84-4436-28　SDHD (Succinate Dehydrogenase Complex Subunit D, PGL, PGL1, QPs3, Succinate-ubiquinone reductase membrane anchor subunit, Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial) 200ul　365014

特徴

• SDHD, which stands for succinate dehydrogenase complex subunit D, is one of the two transmembrane subunits of the four-subunit succinate dehydrogenase protein complex that resides in the inner mitochondrial membrane.
• It also refers to the gene that codes for this protein.
• Germline mutations in SDHD were first linked to hereditary paraganglioma in 2000.
• Since then, it has been shown that mutations in SDHB and to a lesser degree SDHC can cause paranglioma as well familial pheochromocytoma.
• Notably, the tumor spectrum is different for the different mutations.
• SDHB mutations often lead to metastatic disease that is extra-adrenal, while SDHD mutation related tumors are more typically benign, originating in the head and neck.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100ELISA: 1:100-1:5000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.