84-4435-59　RT3 (Reverse Triiodothyronine, RT3, r-T3, Reverse T3, (2S)-2-Amino-3-[4-(4-Hydroxy-3, 5-Diiodophenoxy)-3-Iodophenyl] propanoic Acid, 3, 3', 5'-Triiodo-L-thyronine) 200ul　364945

特徴

• Reverse triiodothyronine is a molecule which is an isomer of triiodothyronine (T3).
• It is derived from thyroxine (T4) through the action of deiodinase.
• rT3, unlike T3, does not stimulate thyroid hormone receptors.
• However, rT3 nonetheless binds to these receptors, thereby blocking the action of T3.
• Under stress conditions, the adrenal glands produce excess amounts of cortisol.
• Cortisol inhibits the conversion of T4 to T3, thus shunting T4 conversion from T3 towards rT3
• Consequently, there is a widespread shutdown in T3 binding across the body.
• This condition is termed Reverse T3 Dominance.
• It results in reduced body temperature, which slows the action of many enzymes, leading to a clinical syndrome, Multiple Enzyme Dysfunction, which produces the effects seen in hypothyroidism.
• Effects include fatigue, headache, migraine, PMS, irritability, fluid retention, anxiety and panic.
• Applications:Suitable for use in ELISA, Immunohistochemistry and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry: 5-20ug/mlImmunocytochemistry: 5-20ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.