The renalase protein is an enzyme which breaks down catecholamines like adrenaline (epinephrine) and noradrenaline (norepinephrine) in the blood circulation.
Researchers at Yale School of Medicine who discovered and named renalase in 2005 suggest that the human kidney releases this protein into the bloodstream to regulate blood pressure
The renalase protein consists of a secretory signal peptide, a flavin adenine dinucleotide (FAD)-binding region, and an amine oxidase domain.
At least four alternative splicing isoforms have been identified in humans (hRenalase1 to hRenalase4).
Only hRenalase1 is detected in human blood samples, which means that hRenalase2 to 4 probably have a different function than hRenalase1.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Optimal dilutions to be determined by the researcher.
AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- ALL RKEITAPLYL ALWDKAGDIG GRMTTANSPH NPRCTADLGA QYITCTPHYA KKHQNFYEEL LAHGILEPLT SPIKGMEVKE GESNFVAPHG VSSIIKYYLK ESGAEVFLRQ CVTQINLRDN KWEVSEDTGS
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes rat RNLS.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Rt
Immunogen：Recombinant protein corresponding to Ala18- Ser150 of rat RNLS, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
