84-4435-08　RETNLb (Resistin Like Beta, XCP2, FIZZ2, HXCP2, CCRG, RETNL2, RELMb, Foundin In Flammatory Zone 2, Colon and small intestine-specific cysteine-rich protein, Colon carcinoma-related gene protein) 200ul　364894

特徴

• The 111aa FIZZ2 protein, which shows 59% sequence identity to mouse Fizz2 and 47% identity to human FIZZ3, shares an N-terminal signal peptide and a C-terminal stretch of 10 cysteine residues with identical spacing with other FIZZ family members.
• Strong expression of mouse Fizz2 mRNA was found in the adult colon in the mucosal crypt epithelial cells.
• Increases in circulating resistin or RELMB levels markedly stimulated hepatic glucose production despite the presence of fixed physiologic insulin levels.
• This enhanced rate of glucose output was due to increased flux through glucose-6-phosphatase.
• The results supported the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Optimal dilutions to be determined by the researcher.
• AA Sequence:MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-QCSFESL VDQRIKEALS RQEPKTISCT SVTSSGRLAS CPAGMVVTGC ACGYGCGSWD IRNGNTCHCQ CSVMDWASAR CCRMA
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.