RARRES1 was identified as a retinoid acid (RA) receptor-responsive gene.
It encodes a type 1 membrane protein.
The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors.
The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island.
Alternatively spliced transcript variant encoding distinct isoforms have been observed.Strong RARRES1 expression could be induced by RAR-specific but not RXR-specific agents.
In situ hybridization analysis showed that treatment of psoriatic rafts or patient skin lesions with tazarotene induces RARRES1 expression.
Nonlesional and sham-treated lesional psoriatic skin showed no expression of RARRES1.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human RARRES1.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Pro43-Phe294 of human RARRES1, fused to two N-terminal Tags, His-Tag and GST-tag, expressed in E. coli.
