84-4434-73　RANTES (Regulated On Activation In Normal T-Cell Expressed And Secreted, CCL5, SCYA5, SISd, EoCP, Chemokine C-C-Motif Ligand 5, Eosinophil Chemotactic Cytokine, T-cell Specific Protein p288, Small Inducible Cytokine Subfamily A(Cys-Cys)Member 5) 200ul　364860

特徴

• Regulated on activation in normal T cell expressed and secreted(RANTES) was identified in 1988, as a result of a subtractive hybridization screen for mRNA expressed by T cells, but not by B cells.
• In addition to T cells, RANTES is also produced by epithelial cells, monocytes, fibroblasts, and mesanglial cells.
• Platelets and eosinophils release RANTES from intracellular storage granules upon activation.
• Several high affinity receptors for RANTES have been described, including CCR1, CCR3, CCR5, and cytomegalovirus receptor US28.
• RANTES also binds to the erythrocyte Duffy antigen receptor (DARC) with low affinity.
• RANTES regulates the trafficking of cells expressing these receptors, including T cells, eosinophils, basophils, monocytes, macrophages, microglia, NK cells, dendritic cells, mast cells, and neurons.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.