84-4434-47　PVRL2 (Poliovirus Receptor Related Protein 2, CD112, HVEB, PRR2, PVRR2, Herpesvirus Entry Mediator B, Herpes virus entry mediator B) 200ul　364834

特徴

• Poliovirus receptor-related 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain.
• This protein is one of the plasma membrane components of adherens junctions.
• It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses.
• Variations in this gene have been associated with differences in the severity of multiple sclerosis.
• Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Expression of PVR or PVRL2 rendered cells susceptible to enhanced lysis in a DNAM1- dependent manner that was nearly abrogated in the presence of antibody to PVR, PVRL2, or DNAM1.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- PANHQ NVAAFHPKMG PSFPSPKPGS ERLSFVSAKQ STGQDTEAEL QDATLALHGL TVEDEGNYTC EFATFPKGSV RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV ALCISKEGRP PARISWLSSL DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV EHESFEEPAL IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP NTA
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.