Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium.
In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b.
The best characterized function of Protein S is its role in the anti coagulation pathway, it functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa.
Only the free form has cofactor activity.
Protein S can bind to negatively charged phospholipids via the carboxylated GLA domain.
This property allows Protein S to function in the removal of cells which are undergoing apoptosis.
Apoptosis is a form of cell death that is used by the body to remove unwanted or damaged cells from tissues.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes rat PROS.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Rt
Immunogen：Recombinant protein corresponding to Pro416-Val646 of rat PROS, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
