Peroxisome proliferator-activated receptor deltais a member of the peroxisome proliferator- activated receptor (PPAR) family.
It was first identified in Xenopus in 1993.
PPAR-delta/Beta is the main target of a chemical substance named GW 501516.
Using this ligand as a research ligand, It has been shown that agonism of PPAR-delta changes the body's fuel preference from glucose to lipids.
PPAR-delta/Beta is highly expressed in colon, small intestine, liver and keratinocytes.
In contrast, heart, spleen, skeletal muscle, lung, brain and thymus show low expression.
Knockout mice lacking the ligand binding domain of PPAR-delta/Beta are viable.
However these mice are smaller than the wild type both neo and postnatally.
In addition, fat stores in the gonads of the mutants are smaller.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes mouse PPARd.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Mo
Immunogen：Recombinant protein corresponding to Thr260-hr426 of mouse PPARd, fused to N-terminal His-Tag expressed in E. coli.
