The main target genes of PNR are rhodopsin and several opsins which are essential for sight.
PNR is part of a large family of nuclear receptor transcription factors involved in signaling pathways.
Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults.
Members of this family are characterized by discrete domains that function in DNA and ligand binding.
This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor.
Defects in this gene are a cause of enhanced S cone syndrome.
Alternatively spliced transcript variants encoding different isoforms have been identified.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human PNR.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Met1-Asn410 of human PNR, fused to two N-terminal Tags, His-Tag and GST-tag, expressed in E. coli.
