PDGFRL is a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta.
Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers.
This suggests this gene product may function as a tumor suppressor
The 375aa protein predicted from this cDNA has hydrophobic sequence at the NH2 terminus, characteristic of signal peptides.
It shows 27% and 25% identity with the extracellular domain of platelet-derived growth factor receptor-beta and FMS-like tyrosine kinase (FLT), respectively.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes mouse PDGFRL.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Mo
Immunogen：Recombinant protein corresponding to Gln22-Ser375 of mouse PDGFRL, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
