Proprotein convertase subtilisin/kexin type 5 is an enzyme belongs to the subtilisin-like proprotein convertase family.
The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products.
This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits.
It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160.
Two alternatively spliced transcripts are described for this gene but only one has its full length nature known.
Expressed in T-lymphocytes.
Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway.
Capable of cleavage at the RX(K/R)R consensus motif.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human PCSK5.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Asp115-Met454 of human PCSK5, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
