The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments.
The first functional designation of this protein was OCTN1 but efficiency of transport for organic cations is very low.
The transport efficiency for carnitine is also negligible.
Instead, the protein is responsible for the cotransport of sodium ions and ergothioneine, which is an antioxidant, into cells.
Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").
Widely expressed.
Highly expressed in whole blood, bone marrow, trachea and fetal liver.
Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord.
Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human OCTN1.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Leu42-Lys141 of human OCTN1, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
