The thyroid hormone receptors (TRs) are hormone-dependent transcription factors that regulate expression of a variety of specific target genes.
In a screen for TR-interacting proteins (TRIPs),The predicted 514aa p59OASL shares a highly conserved N-terminal domain with other OASs.
The C-terminal portion of p59OASL contains 2 ubiquitin-like domains.
Northern blot analysis revealed that p59OASL is expressed in most tissues, with the highest levels in primary blood leukocytes and other hematopoietic system tissues, colon, and stomach.
p59OASL transcription is induced by interferon.
The p59OASL gene contains 6 exons.
Exons 1-5 are similar in structure to exons 3-7 of OAS1, suggesting that the 2 genes arose from a duplication of an ancestral gene.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human OASL.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Ala2-Trp244 of human OASL, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
