Inversin, also known as INVS is a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains.
The encoded protein may function in renal tubular development and function, and in left-right axis determination.
This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination.
A similar protein in mice interacts with calmodulin.
Mutations in this gene have been associated with nephronophthisis type 2.
Two transcript variants encoding distinct isoforms have been identified for this gene
Required for normal renal development and establishment of left-right axis.
Widely expressed.
Strongly expressed in the primary cilia of renal tubular cells.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human NPHP2.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Met1-Val237 of human NPHP2, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
