Neuromedin S is found in the brain of humans and other mammals.
It is produced in the suprachiasmatic nucleus of the hypothalamus and is related to neuromedin U.
It is thought to be involved in regulation of circadian rhythm and also has appetite suppressant effects, as well as regulating the release of several other peptide hormones including vasopressin, luteinizing hormone, and oxytocin.
Neuromedin S, a novel neuropeptide of 36aa, was isolated from rat brain as an endogenous ligand for the orphan Gprotein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, identified to date as type-1 and type-2 NMU receptors, respectively.
The peptide was designated neuromedinS (NMS) because it is specifically expressed in the suprachiasmatic nucleus of the hypothalamus.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 0.5-2ug/ml Immunohistochemistry: 5-20ug/ml Immunocytochemistry: 5-20ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
Specificity：Recognizes mouse NMS.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Mo
Immunogen：Recombinant protein corresponding to aa31-153 of mouse NMS expressed in E. coli.
