84-4429-49　NF2 (Neurofibromin 2, ACN, BANF, SCH, Merlin, Bilateral Acoustic Neuroma, Schwannomin, Schwannomerlin, Moesin-Ezrin-Radixin-Like Protein) 200ul　364341

特徴

• Merlin is a cytoskeletal protein.
• In humans, it is a tumor suppressor protein involved in Neurofibromatosis type II.Sequence data reveal its similarity to the ERM protein family.
• The name "merlin" is an acronym for "Moesin-Ezrin-Radixin-Like Protein".
• Human merlin is coded by the gene NF2 in Chromosome 22.
• Mouse merlin gene is located on the chromosome 11 and rat merlin gene on the chromosome 17.
• Fruit fly merlin gene (symbol Mer) is located on chromosome 1 and shares 58% similarity to its human homologue.
• Other merlin-like genes are known from a wide range of animals, and the derivation of merlin is thought to be in early metazoa.
• Merlin is a member of the ERM family of proteins including ezrin, moesin, and radixin, which are in the protein 4.1 superfamily of proteins.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- D AEMEFNCEMK WKGKDLFDLV CRTLGLRETW FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDAL
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.