84-4429-21　NCF2 (Neutrophil Cytosolic Factor 2, NOXA2, p67phox, 65kD, Chronic Granulomatous Disease,Autosomal 2, NADPH Oxidase Activator 2, 67kD neutrophil oxidase factor, Neutrophil NADPH oxidase factor 2) 200ul　364313

特徴

• Neutrophil cytosol factor 2 is the 67kD cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils.
• This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome.
• Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease
• Using neutrophils from a patient with p67-deficient CGD, Okamura et al.
• (1990) confirmed that the p67 protein functions in the respiratory burst mediated by NADPH oxidase and that p67 may be complexed to p47-phox (NCF1) while it participates in oxidase activation.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- KVHYKY TVVMKTQPGL PYSQVRDMVS KKLELRLEHT KLSYRPRDSN ELVPLSEDSM KDAWGQVKNY CLTLWCENTV GDQGFPDEPK ESEKADANNQ TTEPQLKKGS QVEALFSYEA TQPEDLEFQE GDIILVLSKV NEEWLEGECK GKVGIFPKVF VEDCATTDLE STRREV
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.