84-4428-87　MYO1G (Myosin IG, Minor Histocompatibility Antigen HA-2) 200ul　364280

特徴

• Precursor of the minor histocompatibility antigen HA-2.
• More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells.
• The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing.
• The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor.
• GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- VRAHLIE LQRRFQAARQ PPLYGRDLVW PTPPAVLQPF QDTCRVLFSR WRARQLVKNI PPSDMIQIKA KVAAMGALQG LRQDWGCQRA WARDYLSSDT DNPTASHLFA EQLKALREKD GFGSVLFSSH VRKVNRFRKS RDRALLLTDR YLYKLEPGRQ YRVMRAVPLE AVTGLSVTSG RDQLVVLHAQ GYDDLVVCLH RSQPPLDNRI GELVGMLAAH CQGEGRTLEV RVSDCIPLSQ RGARRLISVE PRPEQPEPDF QSSRSTFT
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.