84-4428-49　MUC1 (Mucin 1, CD227, EMA, H23AG, KL-6, PEM, PEMT, PUM, CA15-3, Cancer antigen 15-3, Carcinoma-associated mucin, Episialin, Peanut-reactive urinary mucin, Polymorphic epithelial mucin) 200ul　364242

特徴

• MUC1 is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type.
• It also includes a 20aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals.
• The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity.
• Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.
• Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100ELISA: 1:100-1:5000Optimal dilutions to be determined by the researcher.
• AA Sequence:MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-MTPGIRVPLL LLLLLASLKV RSGASSSTTS LPGDSFSTAV PSGASSSATS PPVDSTTSPV HSSTSFPATS PPGDSTSTAV LSGDSDPATS PPGDSSSTAV PNGASSSATS PPVDSTTSPV HSSTSFPATS SPGDSTSTAV TSGTSSSATS PPEDSSSTAV TSGTSSPATS PPGDSSSTAV TSGTSSPATS PILDSSSTAV LSGTSSPATS PPEDSTSTAV TSGTSSPATS PPEDSTSTAV TSGTSSPATS PILDSSSTAI HSGTSSPATS PPGDSSSTAV LSGASTQTTK AVSDLASTPT HNGIMVPTTW SALSSATSPV YSGSSATTNS SESDMATTPV YSGTPFSSTT
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.