MTA2 has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells.
It shows a very broad expression pattern and is strongly expressed in many tissues.
It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation.
Their indirect effects on transcriptional regulation may include chromatin remodeling.
It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas.
These two proteins are so closely related that they share the same types of domains.
These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human MTA2.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Met1-Cys394 of human MTA2, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
