Matrix metalloproteinase 23a (MMP23a) lacks the signal sequence found in other MMPs, suggesting that it may function intracellularly.
The substrate for the enzyme has not been identified, but it is thought that the protein may play a role in reproductive processes.
The MMP23A gene is part of a duplicated region of chromosome 1p36.3, which includes a second gene, MMP23B, which is almost identical
The matrix metalloproteinases are secreted glycoproteins that are involved in the remodeling of the extracellular matrix.
By analysis of the genomic region surrounding the duplicated genes CDC2L1 and CDC2L2, Gururajan et al.
(1998) identified 2 novel matrix metalloproteinase genes, MMP23A, which they called MMP21, and MMP23B, which they called MMP22.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
仕様
Size：200ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes rat MMP23A.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Rt
Immunogen：Recombinant protein corresponding to Ser71-Tyr383 of rat MMP23A, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
