84-4427-49　MHCDRb1 (Major Histocompatibility Complex Class II DR Beta 1, HLA-DRB1, HLA-DR1B, HLADRb1, HLA Class II Histocompatibility Antigen,DRB1-9 Beta Chain, HLA class II histocompatibility antigen, DRB1-15 beta chain) 200ul　364143

特徴

• HLA class II histocompatibility antigen, DRB1-9 beta chain belongs to the HLA class II beta chain paralogues.
• The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane.
• It plays a central role in the immune system by presenting peptides derived from extracellular proteins.
• Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages)
• The beta chain is approximately 26-28kD.
• It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
• Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap