Protein max is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors.
It is able to form homodimers and heterodimers with other family members, which include Mad, Mxl1 and Myc.
MAX Gene Associated Protein functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box familyarget genes.
Functions as a repressor or an activator.
Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes.
Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation.
Function activated by heterodimerization with MAX.
This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human MgA.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Thr2450-Lys2733 of human MgA, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
