84-4426-36　LY75 (Lymphocyte Antigen 75, CD205, LY75, CLEC13B, DEC-205, GP200-MR6, C-type lectin domain family 13 member B) 200ul　364030

特徴

• The LY75 protein has 77% overall aa identity with mouse Dec205.
• LY75 is a member of the MMR family of multidomain molecules.
• It contains a signal peptide, a cysteine-rich domain, a fibronectin type II domain, 10 carbohydrate recognition-like domains, a transmembrane domain, and a cytoplasmic tail.
• Northern blot analysis of hematopoietic cell lines revealed the presence of a predominant 7.8kb and a secondary 9.5kb transcript in myeloid, B-cell, and Hodgkin cell lines but not in the Jurkat T-cell line.
• In peripheral blood, immature DC contained barely detectable transcripts, which increased 50-fold upon differentiation and activation.
• LY75 acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- CEGNW EKNEQIGSCY QFNNQEILSW KEAYVSCQNQ GADLLSIHSA AELAYITGKE DIARLVWLGL NQLYSARGWE WSDFRPLKFL NWDPGTPVAP VIGGSSCARM DTESGLWQSV SCESQQPYVC KKPLNNTLEL PDVWTYTDTH CHVGWLPNNG FCYLLANESS SWDAAHLKCK AFGADLISMH SLADVEVVVT KLHNGDVKKE IWTGLKNTNS PALFQWSDGT EVTLTYWNEN EPSVPFNKTP NCVSYLGKLG QWKVQSCEKK LRYVCKKKGE ITKDAESDKL CPP
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.